Matteuinterins A–C, three new glycosides from the rhizomes of Matteuccia intermedia

Phytochemical investigation on the rhizomes of Matteuccia intermedia C.Chr. led to the isolation of three new compounds, named matteuinterins A–C (1–3), together with seven known compounds (4–10). Their structures were elucidated by extensive NMR analyses and chemical derivatization. Compounds 5–10 were evaluated for their anti-inflammatory activities on PGE₂ release in LPS-stimulated RAW 264.7 murine macrophages. Compounds 5 and 10 exhibited inhibitory effect on PGE₂ production in LPS-activated murine macrophages with IC₅₀ values of 17.8 ± 1.5 and 30.3 ± 2.1 μM, respectively.