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Matteuinterins A–C, three new glycosides from the rhizomes of Matteuccia intermedia

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journal contribution
posted on 04.11.2019 by Xue Li, Li-Ting Niu, Wei-Tong Meng, Ling-Juan Zhu, Xue Zhang, Xin-Sheng Yao

Phytochemical investigation on the rhizomes of Matteuccia intermedia C.Chr. led to the isolation of three new compounds, named matteuinterins A–C (1–3), together with seven known compounds (4–10). Their structures were elucidated by extensive NMR analyses and chemical derivatization. Compounds 510 were evaluated for their anti-inflammatory activities on PGE2 release in LPS-stimulated RAW 264.7 murine macrophages. Compounds 5 and 10 exhibited inhibitory effect on PGE2 production in LPS-activated murine macrophages with IC50 values of 17.8 ± 1.5 and 30.3 ± 2.1 μM, respectively.

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