gnpl_a_1577840_sm4639.pdf (10.52 MB)
Neo-debromoaplysiatoxin C, with new structural rearrangement, derived from debromoaplysiatoxin
journal contribution
posted on 2019-03-05, 21:48 authored by Yang-Hua Tang, Ting-Ting Liang, Ting-Ting Fan, Lawrence Jordan Keen, Xiao-Dan Zhang, Lin Xu, Qi Zhao, Rong Zeng, Bing-Nan HanNeo-debromoaplysiatoxin C (1), a new member of the aplysiatoxin family, was isolated from the marine cyanobacterium Lyngbya sp. The structure of 1 was elucidated based on spectroscopic data, and its stereochemistry was determined from NOESY spectrum and biosynthetic considerations. This new compound presents an intriguing 10-membered lactone ring skeleton derived from debromoaplysiatoxin by structural rearrangement, which is the first example in the aplysiatoxin family. Its biological properties were evaluated for cytotoxicity, PKCδ activation and inhibitory effects on potassium channel.