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One new sesquiterpene pyridine alkaloid from the stems and leaves of Euonymus fortunei

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journal contribution
posted on 2020-04-22, 09:41 authored by Guang-Kai Kuang, Lin Wang, Li-Li Yang, Yu-Bo Zhang, Ding Luo, Yi-Duo Zhou, Neng-Hua Chen, Zhong-Nan Wu, Guo-Cai Wang, Yao-Lan Li

A new sesquiterpene pyridine alkaloid (1), along with four known compounds (2-5), were isolated from the stems and leaves of Euonymus fortunei. The new structure was determined by extensive spectroscopic analyses (IR, UV, NMR, HRESIMS and ECD). In addition, compound 3 showed a stronger anti-respiratory syncytial virus (RSV) activity with an IC50 value of 1.20 ± 0.10 µM than the positive control ribavirin with an IC50 value of 5.62 ± 0.49 µM.

Funding

This work was financially supported by grants from the National Key R&D Program of China (No. 2017YFC1703800), Natural Science Foundations of China (Nos. 81803376, 81673319, and 81673670), Science and Technology Planning Project of Guangzhou City (Nos. 201904010447, 201707010399), Natural Science Foundation of Guangdong Province (No. 2018B030311020, 2017A030313732), China Postdoctoral Science Foundation (No. 2019T120795), and Science and Technology Planning Project of Shenzhen City (JCYJ20170818162249554).

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    Journal of Asian Natural Products Research

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    Keywords

    CelastraceaeEuonymus fortuneisesquiterpene pyridine alkaloidanti-RSV activity

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    CC BY 4.0

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