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Palladium-catalyzed facile synthesis of furoquinolinones and furopyridinones

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posted on 13.02.2018 by Tao Guo, Xu-Ning Wei, Hong-Yan Wang, Bing Zhao

This work is focused on the development of a convenient and efficient approach for the synthesis of furoquinolinones and furopyridinones through palladium-catalyzed cyclization reactions between styrenes and 4-hydroxyquinolinones/4-hydroxypyridinones under air conditions. Studies conducted to evaluate the antitumoral potential of the resulted compounds revealed that some of the obtained furoquinolinones exhibited in vitro antiproliferative activity on human-derived stomach cancer cell lines.

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