gnpl_a_1700253_sm3019.pdf (2.05 MB)
0/0

Sulphated flavones and pregnane-type steroids from Helicteres viscida

Download (2.05 MB)
journal contribution
posted on 10.12.2019 by Luu Hong Truong, Nguyen Hieu Cuong, Tran Huu Dang, Trinh Thi My Dung, Pham Thi Cham, Tran Thi Hong Hanh, Tran Hong Quang, Nguyen Hai Dang, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh

In our search for anti-inflammatory constituents from Vietnamese plants, the methanolic extract of Helicteres viscida was found to exhibit inhibitory effect on LPS-induced NO production in RAW264.7 cells. Phytochemical investigation of this plant led to isolation of four sulphated flavones (1–4), including one new compound 5,3′,4′-trihydroxy-7-methoxy-8-O-sulphate flavone (1), and two pregnane-type steroids (5 and 6), including one new compound 7-epi-heligenin B (5). Their structures were elucidated by 1D and 2D NMR as well as HR-QTOF-MS experiments. Among isolated compounds, heligenin B (6) exhibited potent inhibitory effect on LPS-induced NO production in RAW264.7 cells with IC50 of 1.23 ± 0.05 µM. The activity of 6 was comparable to that of the positive control cardamonin.

Funding

This research is funded by a grant from Vietnam Academy of Science and Technology (code: VAST.UDCN01/17-19).

History

Licence

Exports