gpss_a_1700258_sm0039.docx (1.73 MB)
Transition metal complexes of α-aminophosphonates part II: Synthesis, spectroscopic characterization, and in vitro anticancer activity of copper(II) complexes of α-aminophosphonates
Version 2 2020-02-11, 12:05
Version 1 2019-12-12, 10:37
journal contribution
posted on 2020-02-11, 12:05 authored by Mariam Ahmed Azzam, Hanaa Abdel Latif El-Boraey, Ibrahim El Tantawy El-SayedA one pot procedure was used to synthesize two new derivatives of α-aminophosphonates. Novel copper(II) complexes of α-aminophosphonates were synthesized by coordinating different copper salts with the newly synthesized α-aminophosphonates. Their structures were characterized by different spectral and analytical techniques. Evaluation of the metal-free ligands HL1, HL2, and their Cu(II) complexes against human colon carcinoma HT-29 cell lines was performed, using cisplatin as a reference drug. The results indicated that the complexes of the ligand HL1 exhibited enhanced anticancer activity, while ligand HL2 complexes showed decreased anticancer activity.