lsyc_a_1672745_sm2483.pdf (1.33 MB)
Condensation of 2-methylindole with acetophenones: An unexpected formation of 2-arylanilines
journal contribution
posted on 2019-10-08, 06:38 authored by Wayland E. Noland, Alexei V. Novikov, Christopher D. Brown2-Methylindole condenses with acetophenones under acidic conditions to produce 2-arylanilines in moderate to good yields. The reaction proceeds well with a range of 3′- and 4′- substituted acetophenones (fluoro-, chloro-, bromo-, iodo-, methyl, methoxy), and select 2′- substituted ones (fluoro-, methoxy-). No products were obtained with nitro- substitution in any position.