lsyc_a_1480041_sm6684.docx (4.33 MB)
Synthesis and antitubercular activity evaluation of 4-furano-coumarins and 3-furano-chromones
journal contribution
posted on 2018-10-08, 16:12 authored by Ankita Singh, Devla Bimal, Rajesh Kumar, Vipin K. Maikhuri, M. Thirumal, Nihar Nalini Senapati, Ashok K. PrasadThe synthesis of novel 4-furano-coumarins and 3-furano-chromones has been achieved using silver-mediated oxidative C–H/C–H functionalization of 4-ethynylcoumarin/3-ethynylchromone with ethyl acetoacetate in 80%–90% and 82%–90% yields, respectively. The structure of the synthesized compounds was established on the basis of their spectral data analysis and the structure of one of the 4-furano-coumarins has been further confirmed on the basis of its X-ray crystallographic study. All eight synthesized 4-furano-coumarins and 3-furano-chromones exhibited moderate antitubercular activity against sensitive reference strain H37Rv of Mycobacterium tuberculosis.